JCSIS
JCSIS

Advanced Neural Network Applications in Bioinformatics for Cancer Detection and Disease Prediction

Khadija ShazlyLima HongouHakan Khan
Volume 4

Abstract

Advanced neural network applications have significantly enhanced bioinformatics approaches for cancer detection and disease prediction. Deep learning models, particularly convolutional neural networks (CNNs) and graph convolutional networks (GCNs), have demonstrated high accuracy in analyzing complex biological data such as gene expression profiles and histopathological images. For instance, a study employing a 4-layer GCN on whole slide images of gastric and colon adenocarcinomas achieved improved survival prediction outcomes, surpassing traditional CNN models. Additionally, integrating noncoding RNA biomarkers with deep learning neural networks has enabled the discrimination of multiple cancer types with high accuracy, facilitating early detection and personalized treatment strategies. These advancements underscore the potential of neural network-based models in transforming cancer diagnostics and prognostics by providing more precise and individualized patient care.


Keywords

Neural Networks, Bioinformatics, Cancer Detection, Disease Prediction, Deep Learning, Graph Convolutional Networks

References

  • [1] El-Kenawy, E. S. M., Ibrahim, A., Mirjalili, S., Eid, M. M., & Hussein, S. E. (2020). Novel feature selection and voting classifier algorithms for COVID-19 classification in CT images. IEEE access, 8, 179317-179335.
  • [2] El-Kenawy, E. S. M., Eid, M. M., Saber, M., & Ibrahim, A. (2020). MbGWO-SFS: Modified binary grey wolf optimizer based on stochastic fractal search for feature selection. IEEE Access, 8, 107635-107649.
  • [3] El-Kenawy, E. S., & Eid, M. (2020). Hybrid gray wolf and particle swarm optimization for feature selection. Int. J. Innov. Comput. Inf. Control, 16(3), 831-844.
  • [4] El-Kenawy, E. S. M., Khodadadi, N., Mirjalili, S., Abdelhamid, A. A., Eid, M. M., & Ibrahim, A. (2024). Greylag goose optimization: nature-inspired optimization algorithm. Expert Systems with Applications, 238, 122147.
  • [5] El-Kenawy, E. S. M., Mirjalili, S., Ibrahim, A., Alrahmawy, M., El-Said, M., Zaki, R. M., & Eid, M. M. (2021). Advanced meta-heuristics, convolutional neural networks, and feature selectors for efficient COVID-19 X-ray chest image classification. Ieee Access, 9, 36019 36037.
  • [6] Abdelhamid, A. A., El-Kenawy, E. S. M., Khodadadi, N., Mirjalili, S., Khafaga, D. S., Alharbi, A. H., ... & Saber, M. (2022). Classification of monkeypox images based on transfer learning and the Al-Biruni Earth Radius Optimization algorithm. Mathematics, 10(19), 3614.
  • [7] Ibrahim, A., Mirjalili, S., El-Said, M., Ghoneim, S. S., Al-Harthi, M. M., Ibrahim, T. F., & El-Kenawy, E. S. M. (2021). Wind speed ensemble forecasting based on deep learning using adaptive dynamic optimization algorithm. IEEE Access, 9, 125787-125804.
  • [8] El-Kenawy, E. S. M., Mirjalili, S., Alassery, F., Zhang, Y. D., Eid, M. M., El-Mashad, S. Y., ... & Abdelhamid, A. A. (2022). Novel meta heuristic algorithm for feature selection, unconstrained functions and engineering problems. IEEE Access, 10, 40536-40555.
  • [9] Abdelhamid, A. A., El-Kenawy, E. S. M., Alotaibi, B., Amer, G. M., Abdelkader, M. Y., Ibrahim, A., & Eid, M. M. (2022). Robust speech emotion recognition using CNN+ LSTM based on stochastic fractal search optimization algorithm. Ieee Access, 10, 49265-49284.
  • [10] Abdollahzadeh, B., Khodadadi, N., Barshandeh, S., Trojovský, P., Gharehchopogh, F. S., El-kenawy, E. S. M., ... & Mirjalili, S. (2024). Puma optimizer (PO): a novel metaheuristic optimization algorithm and its application in machine learning. Cluster Computing, 27(4), 5235-5283.
  • [11] Eid, M. M., El-kenawy, E. S. M., & Ibrahim, A. (2021, March). A binary sine cosine-modified whale optimization algorithm for feature selection. In 2021 National Computing Colleges Conference (NCCC) (pp. 1-6). IEEE.
  • [12] El-Kenawy, E. S. M., Mirjalili, S., Abdelhamid, A. A., Ibrahim, A., Khodadadi, N., & Eid, M. M. (2022). Meta-heuristic optimization and keystroke dynamics for authentication of smartphone users. Mathematics, 10(16), 2912.
  • [13] Abdelhamid, A. A., Towfek, S. K., Khodadadi, N., Alhussan, A. A., Khafaga, D. S., Eid, M. M., & Ibrahim, A. (2023). Waterwheel plant algorithm: a novel metaheuristic optimization method. Processes, 11(5), 1502.
  • [14] Alhussan, A. A., Abdelhamid, A. A., El-Kenawy, E. S. M., Ibrahim, A., Eid, M. M., Khafaga, D. S., & Ahmed, A. E. (2023). A binary waterwheel plant optimization algorithm for feature selection. IEEE Access, 11, 94227-94251.
  • [15] Hassib, E. M., El-Desouky, A. I., Labib, L. M., & El-Kenawy, E. S. M. (2020). WOA+ BRNN: An imbalanced big data classification framework using Whale optimization and deep neural network. soft computing, 24(8), 5573-5592.
  • [16] El-Kenawy, E. S. M., Abdelhamid, A. A., Ibrahim, A., Mirjalili, S., Khodadad, N., Alduailij, M. A., ... & Khafaga, D. S. (2023). Al-Biruni Earth Radius (BER) Metaheuristic Search Optimization Algorithm. Comput. Syst. Sci. Eng., 45(2), 1917-1934.
  • [17] Alharbi, A. H., Towfek, S. K., Abdelhamid, A. A., Ibrahim, A., Eid, M. M., & Khafaga, D. S. & Saber, M.(2023). Diagnosis of Monkeypox Disease Using Transfer Learning and Binary Advanced Dipper Throated Optimization Algorithm. Biomimetics, 8(3), 313.
  • [18] El-Kenawy, E. S. M., Mirjalili, S., Khodadadi, N., Abdelhamid, A. A., Eid, M. M., El-Said, M., & Ibrahim, A. (2023). Feature selection in wind speed forecasting systems based on meta-heuristic optimization. Plos one, 18(2), e0278491.
  • [19] Khodadadi, N., Abualigah, L., El-Kenawy, E. S. M., Snasel, V., & Mirjalili, S. (2022). An archive-based multi-objective arithmetic optimization algorithm for solving industrial engineering problems. IEEE Access, 10, 106673-106698.
  • [20] Eid, M. M., El-Kenawy, E. S. M., Khodadadi, N., Mirjalili, S., Khodadadi, E., Abotaleb, M., ... & Khafaga, D. S. (2022). Meta-heuristic optimization of LSTM-based deep network for boosting the prediction of monkeypox cases. Mathematics, 10(20), 3845.
  • [21] Khodadadi, N., Khodadadi, E., Al-Tashi, Q., El-Kenawy, E. S. M., Abualigah, L., Abdulkadir, S. J., ... & Mirjalili, S. (2023). BAOA: binary arithmetic optimization algorithm with K-nearest neighbor classifier for feature selection. IEEE Access, 11, 94094-94115.
  • [22] Salamai, A. A., El-kenawy, E. S. M., & Abdelhameed, I. (2021). Dynamic voting classifier for risk identification in supply chain 4.0. Computers, Materials & Continua, 69(3).
  • [23] Djaafari, A., Ibrahim, A., Bailek, N., Bouchouicha, K., Hassan, M. A., Kuriqi, A., ... & El-Kenawy, E. S. M. (2022). Hourly predictions of direct normal irradiation using an innovative hybrid LSTM model for concentrating solar power projects in hyper-arid regions. Energy Reports, 8, 15548-15562.